The U.S. Centers for Disease Control and Prevention (CDC) recently updated their Guideline to Prevent Catheter Associated Urinary Tract Infections (CAUTI). The original guideline was published in 1981. The new guideline includes the latest evidence-based practices and technological advancements for the prevention of CAUTI. It is also the first CDC guideline to be released following the new HICPAC standardized methodology, which incorporates the latest systematic, transparent review of clinical evidence.